Treating the Toughest Cases of Depression and Brain Illness

Steve Best, M.D.

Director, The Neuroscience Center

Steve Best, M.D. provides the highest level of neuropsychiatric, and psychiatric care to child and adult patients suffering from complex illnesses, treatment-resistant illnesses, and high-comorbidity disorders. Dr. Steve Best is board certified in psychiatry and has been the director of The Neuroscience Center in Deerfield, Illinois since 1996. He specializes in brain disorders that affect emotional health, cognitive ability and everyday behavior.

His professional interests are:

  • Treatment resistance (for mood, pain, consequences of stroke, dementia, concussion & TBI)
  • Disorders of learning/learning disability/learning differences/developmental disorders
Dr. Steve Best, Director of the Neuroscience Center


Dr. Best’s projects include:

  • His patented combination therapy to decrease the effects of chronic depression, substance abuse, and chronic pain by harnessing the synergistic effect of TMS or tES with infused ketamine;
  • Targeted intervention of the inflammatory aspects of neurologic and neuropsychiatric illnesses with immune modulation by direct application of TNF inhibitors
  • Hyperbaric Oxygen Therapy in a custom designed multi-place chamber that can accommodate patients along with their own caregivers in our adjoining Hyperbaric Center or traditional monoplace chambers
  • Nutrition-based management of debilitation and inborn errors of metabolism
  • Ketamine-Assisted Psychotherapy for trauma and recalcitrant psychological afflictions


Dr. Best earned his medical degree at the University of Cincinnati and completed a two-year sub-specialty fellowship in Neuropsychiatry of Children and Adults at Chicago Medical School.

His Chicago Medical School Fellowship mentors were Michael Alan Taylor M.D as Chairman of Psychiatry and Dragomir Michael Vuckovich M.D. as Chairman of Neurology.

During these fellowships, he was trained in the application of functional brain imaging (PET) to Neuropsychiatry by Malcolm Cooper, M.D. He provided neuropsychiatric consultations at Ann Kiley Center in North Chicago, IL, a State of Illinois facility for the subset of Developmentally Disabled adults who suffer with severe behavior or psychiatric disorders. In addition, Dr. Best worked with a large Inpatient Child & Adolescent Psychiatry Group Practice.

Private Practice

Best’s mentor Dr. Vuckovich bequeathed his private neuropsychiatry practice to Dr. Best, and the practice has been expanded in multiple ways. His intense training and expertise has enabled Dr. Best to provide the highest level of neuropsychiatric, neurological and psychiatric care to child and adult patients suffering from complex illnesses, treatment resistant illnesses, and high-comorbidity disorders.

Post-Fellowship Training

Dr. Best has had post-fellowship training in Psychopharmacology and is a member of ASCP (American Society of Clinical Psychopharmacology) and SOBP (Society of Biological Psychiatry). He has benefited from unique training in Brain Stimulation by some of the founders of external neuromodulation. He acquired the scientific and clinical training relevant to rTMS (repetitive Transcranial Magnetic Stimulation) in 1999 and later in VNS (Vagal Nerve Stimulation) in 2005, both at the Medical University of South Carolina in their Brain Stimulation Lab. In 2008, he trained in the theoretical basis and  clinical application of tES (transcranial low voltage electrical stimulation such as tDCS, tACS, tRNS) at the University of Göttingen in Germany. Dr. Best is a member of numerous professional Societies.

Dr. Best is licensed in Illinois, New York, California, and Texas.

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